LightSeed LLC was initially established as a Delaware Corporation in 2006 (Entity ID:
06698443) and changed its name to LightSeed LLC in 2016.
LightSeed LLC is a biotechnology company that is developing technology to:
1. Prevent cardiac toxicity from chemotherapy and radiation.
Cardiac toxicity is a serious consequence of cancer therapies (Chemotherapies, Targeted therapies and Radiation).
https://www.nccn.org/patients/resources/life_with_cancer/managing_symptoms/cardiac_toxicity.aspx
2. Allow selective introduction for gene therapy at a single cell level.
LightSeed LLC integrates two type of technologies in order to provide more precise therapies for human disease.
1. Precision gene therapy has been developed through a series of milestones illustrated to the left. Current development (H-L).
2. Cardioprotection from chemotherapy.
Cardiotoxicity from breast cancer therapies can be serious. Seriousness ranges from overt clinical symptoms requiring urgent hospital admission, to an asymptomatic detectable structural change on cardiac imaging or new onset arrhythmia, to a measurable biomarker rise before symptomatic, structural or electrical change is detectable.
Anthracyclines can cause heart toxicity. Anthracyclines used to treat many types of cancers. Examples include some types of leukemia, lymphoma, sarcomas as well as bladder, bone, breast, head and neck, kidney, skin, stomach, and other cancers. Anthracyclines include:
Daunorubicin (Cerubidine®),
Targeted therapy drugs that can cause damage to the heart include
trastuzumab (Herceptin®),
These drugs are used in a variety of cancer types.
Breast cancer (BCa) causes the death of >40,000 women in the USA and 410,000 women in the world annually. 20% to 30% of patients with early BCa will experience relapse with distant metastatic disease, with metastasis as the main cause of death.
Patients with basal tumors, including Triple negative BCa (TNBC)(the absence of AR, ERa, and HER-2), have increased risk of metastasis and lower survival rate.
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